The Voltage-Dependent Anion Channel is involved in the mechanism of cytochrome c release from the mitochondrial intermembrane space into the cytosol. VDAC was shown to interact with Bcl-XL, Bax and Bax. Bcl-XL decreased the conductivity of VDAC, whereas Bax and Bak increased the conducticity of VDAC. Bax and Bak also induced VDAC to be permeable for cytochrome c. Moreover, mitochondria from VDAC-deficient yeast did not release cyto c in presence of Bax, but mitochondria from VDAC-deficient yeast reconstituted with the human vdac gene released cyto c in presence of Bax (Shimizu et al., 1999, Nature, 399: 483). VDAC might also interact with ANT or other components of the PT pore.

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