Liddle Syndrome is characterized by hypertension due to a tendency of the kidney to conserve Na+ and excrete K+ despite the virtual absence of mineralcorticoids. The disorder has been localized to a specific mutation in the epithelial Na+ channel (ENaC) located in the collecting duct of the kidney. Certain ENaC mutations involve deletions in the PPXY motif which is responsible for the recognition and ubiquitination of ENaC by the E3 enzyme Nedd4, suggesting a dysregulated, i.e. increased number of channel molecules contributing to the hypertension seen in Liddle syndrome.
lpr = Lymphoproliferation; spontaneous loss-of-function mutation in the Fas gene of mice. Leads to accumulation of lymphocytes.
Swollen, firm and possibly tender lymph glands. The cause may range from a temporary infection such as the flu, HIV, mononucleosis, to lymphoma (cancer of the lymph nodes).
Lymphoma is a general term for cancers that develop in the LYMPHATIC SYSTEM, affecting the body's IMMUNE SYSTEM. Most lymphomas develop in the lymph nodes, with the rest arising in lymphoid tissue elsewhere in the body. There are two basic kinds of lymphomas: HODGKIN'S DISEASE and NON-HODGKIN'S LYMPHOMA (which is composed of a number of different lymphomas). Hodgkin's disease has unique characteristics that distinguish it from the other lymphomas. It is identified by the presence of the REED-STERNBERG CELL and is more likely to follow a more predictable and limited pattern of spread than that of the other lymphomas, thereby giving it a better PROGNOSIS. Non-Hodgkin's lymphomas are more likely to develop outside the lymph nodes, in organ such as the bones and liver, than is Hodgkin's disease.
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